Sputum Analysis for Lung Cancer has Gone Molecular Level
Lung cancer is one of the most common
cancer killers world-wide. It is important to diagnose the disease in early
stage as the prognosis improves with early diagnosis and treatment.
Sputum
cytology, bronchial brush/ lavage, FNA cytology and biopsy are the frequent
diagnostic modalities for lung cancer. Molecular markers for lung cancer have
been tested in the sputum with promising results. KRAS mutation, p53 mutation,
DNA hypermethylation, microsatellite instability, microRNA analysis etc are
under research with promising results. But these markers are not sufficiently
validated to put into clinical application.
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